研究業績

研究室論文発表

2024年から過去5年間の主要な論文を記載

  1. Sakao K*, Hamamoto S, Urakawa D, He Zi, Hou DX : Anticancer Activity and Molecule Mechanisms of Acetylated and Methylated Quercetin in Human Breast Cancer Cells. Molecules 29(10):2408 (2024), 10.3390/molecules29102408

  2. Sakao K, Sho C, Miyata T, Takara K, Oda R, Hou DX : Verification of In Vitro Anticancer Activity and Bioactive Compounds in Cordyceps Militaris-Infused Sweet Potato Shochu Spirits. Molecules 29(9):2119 (2024), doi: 10.3390/molecules29092119

  3. Kido M, Yoshimoto M, Sakao K, Wada, K, Hou DX : Effects of Cooking Methods on Caffeoylquinic Acids and Radical Scavenging Activity of Sweet Potato. Foods 13 (7): 652 (2024), doi:10.3390/foods13071101

  4. Mukai R, Okuyama H, Uchimura M, Sakao K, Matsuhiro M, Ikeda-Imafuku M, Ishima Y, Nishikawa M, Ikushiro S, Tai A : The binding selectivity of quercetin and its structure-related polyphenols to human serum albumin using a fluorescent dye cocktail for multiplex drug-site mapping. Bioorganic Chemistry 145: 107184 (2024), doi: 10.1016/j.bioorg.2024.107184

  5. Nakamura M, Urakawa D, He Zi, Hou DX, Sakao K*: Apoptosis induction in HepG2 and HCT116 cells by a novel quercetin-zinc (II) complex: Enhanced absorption of quercetin and zinc (II). International Journal of Molecular Sciences 24 (24): 17457 (2023), doi: 10.3390/ijms242417457  * Corresponding Author

  6. Sakao K, Saruwatari H, Minami S, Hou DX: Acetylation of quercetin hydroxyl group enhances anticancer activity by improving the intracellular absorption. International Journal of Molecular Sciences 24 (23): 16652 (2023), doi: 10.3390/ijms242316652

  7. Nakano H, Sakao K, Wada K, Hou DX : Ameliorative effects of anthocyanin metabolites on western diet-induced NAFLD by modulating co-occurrence networks of gut microbiome. Microorganisms 11 (10): 2408 (2023), doi: 10.3390/microorganisms11102408

  8. Orita T, Chogahara S, Okuda M, Sakao K, Miyata T, Hou DX: Extraction efficiency and alpha-glucosidase inhibitory activities of green tea catechins by different infusion methods. Foods, 12 (13): 2611 (2023), doi: 10.3390/foods12132611

  9. Nakano H, Setoguchi S, Kawano K, Miyagawa H, Sakao K, Hou DX: Effects of amazake produced with different Aspergillus on gut barrier and microbiota. Foods, 12 (13): 2568 (2023), doi: 10.3390/foods12132568

  10. Yi S, Chen K, Sakao K, Ikenaga M, Wang Y, Hou DX: Assessment of areca nut bioactivities in Western diet-induced mice NAFLD model. Nutrients, 15 (10): 2403 (2023), doi: 10.3390/ nu15102403

  11. Yi S, Zou L, Li Z, Sakao K, Wang Y, Hou DX: In Vitro antioxidant activity of areca nut polyphenol extracts on RAW264.7 cells. Foods, 11 (22): 3607 (2022), doi:10.3390/foods 11223607

  12. Chen K, Nakasone Y, Yi S, Ibrahim HR, Sakao K, Hossain MA, Hou DX: Natural garlic organosulfur compounds prevent metabolic disorder of lipid and glucose by increasing gut commensal Bacteroides acidifaciens. Journal of Agricultural and Food Chemistry, 70 (19): 5829-5837 (2022)

  13. Miyata T, Mnamihata K, Kurihara K, Kamizuru Y, Gotanda M, Obayashi M, Kitagawa T, Sato K, Kimura M, Oyama K, Ikeda Y, Tamaki Y, Lee JM, Sakao K, Hamanaka D, Kusakabe T, Tachibana M, Ibrahim HR: Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25, by silkworm and its biochemical analysis. Protein Expression and Purification, 195-196: 106096 (2022), doi: 10.1016/j.pep.2022.106096

  14. Pan X, Xie K, Chen K, He Z, Sakao K, Hou DX: Involvement of AMP-activated protein kinase α/nuclear factor (Erythroid-derived 2) like 2-initiatived signaling pathway in cytoprotective effects of Wasabi 6-(methylsulfinyl) hexyl isothiocyanate. Journal of Cancer Prevention, 27(1): 58-67 (2022)

  15. Nakamura K, Shimamoto S, Yamamoto M, Sakao K, Ohtsuka A, Ijiri D: Effects of supplementation with thinned Tankan (Citrus tankan Hayata) on the lipid peroxidation, drip-loss, and color of the pectoralis major muscle of broiler chickens. Journal of Warm Regional Society of Animal Science, 65 (1): 17-24 (2022)

  16. Isao Okunishi, Tomoe Yamada-Kato, Jiro Saito, De-Xing Hou: Safety evaluation of 6-(methylsulfinyl) hexyl isothiocyanate (6-MSITC) and Wasabi sulfinyl, a 6-MSITC containing supplement. Food Science and Technology Research. 26(6),（2020）
  17. Nakano H, Wu S, Sakao K, Hara T, He J, Garcia S, Shetty K, Hou DX. Bilberry Anthocyanins Ameliorate NAFLD by Improving Dyslipidemia and Gut Microbiome Dysbiosis. Nutrients.12(11):E3252.( 2020)
  18. Sakao, K., Hou DX Effects and mechanisms of acylated flavonoid on cancer chemopreventive activity. Current Pharmacol Rep, 5: 286-305 (2020)
  19. Xie K, He X, Chen K, Chen J, Sakao K, Hou DX, Antioxidant Properties of a Traditional Vine Tea, Ampelopsis grossedentata. , Antioxidants (Basel, Switzerland);8(8):295. doi: 10.3390/antiox8080295 (2020)
  20. Xie K , He X , Chen K , Sakao K , Hou DX .　Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. Food Funct. 11(7):5976-5991.(2020)
  21. Chen K, Nakasone Y, Xie K, Sakao K, Hou DX.　Modulation of Allicin-Free Garlic on Gut Microbiome. Molecules. 25(3):682 (2020)
  22. Chen K, Xie K, Liu Z, Nakasone Y, Sakao K, Hossain A, Hou DX, Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis., Nutrients 11(6) （2019）
  23. Yano S, Wu S, Sakao K, Hou DX. Involvement of ERK1/2-mediated ELK1/CHOP/DR5 pathway in 6-(methylsulfinyl)hexyl isothiocyanate-induced apoptosis of colorectal cancer cells. Biosci Biotechnol Biochem. 83(5):960-969 (2019)

2018年以前の主要な論文を記載

  1. Yano S, Wu S, Sakao K, Hou DX. Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway. Biofactors. （2018 ）
  2. Trio PZ, Kawahara A, Tanigawa S, Sakao K, Hou DX*. DNA microarray profiling highlights Nrf2-mediated chemoprevention targeted by wasabi-derived isothiocyanates in HepG2 cells. Nutr Cancer. 69(1):105-116 (2017).
  3. Trio PZ, Fujisaki S, Tanigawa S, Hisanaga A, Sakao K, Hou DX*. DNA microarray highlights Nrf2-mediated neuron protection targeted by Wasabi-derived isothiocyanates in human IMR-32 cells. Gene Regul Syst Bio. 10:73-83 (2016).
  4. Hisanaga A, Mukai R, Sakao K, Terao J, Hou DX*. Anti-inflammatory effects and molecular mechanisms of 8-prenyl quercetin. Mol Nutr Food Res.60(5):1020-1032(2016).
  5. Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J. Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice. J Nutr Biochem. 31:67-76 (2016).
  6. 章超、坂尾こず枝、小野友愛、髙瀬良和、岩井謙一、侯德興*：サツマイモ焼酎の冬虫夏草スピリッツの抽出物の機能性解析：①ヒト大腸癌細胞における細胞増殖抑制及びアポトーシス誘導作用. 日本醸造協会誌、110(2): 110-116 (2015).
  7. Sogo T, Kumamoto T, Ishida H, Hisanaga A, Sakao K, Terahara N, Wada K, Hou DX*: Comparison of the Inhibitory Effects of Delphinidin and Its Glycosides on Cell Transformation. Planta Medica 81(1):26-31(2015).
  8. Sogo T, Terahara N, Hisanaga A, Kumamoto T, Yamashiro T, Wu S, Sakao K, Hou DX*. Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, a Hibiscus anthocyanin. Biofactors. 41(1):58-65(2015).
  9. 章超、久永絢美、坂尾こず枝、廣眞梨子、髙瀬良和、岩井謙一、侯德興*：サツマイモ焼酎の冬虫夏草スピリッツの抽出物の機能性解析：②培養細胞及びマウスモデルにおける抗炎症作用.日本醸造協会誌、110(3):170-178 (2015).
  10. 章超、坂尾こず枝、矢野敏史、永絢美、髙瀬良和、岩井謙一、侯德興*：サツマイモ焼酎の冬虫夏草スピリッツの抽出物の機能性解析③：ヒト急性前骨髄性白血病細胞に対する抗癌活性.日本醸造協会誌、110(6):444-452 (2015).
  11. Wu SS, He X, Wu XS, Qin S, He JH, Zhang SR, Hou DX*.: Inhibitory effects of blue honeysuckle (Loniceracaerulea L) on adjuvant-induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects. Journal of Functional Foods 17: 514-523(2015).
  12. 章超、坂尾こず枝、小野友愛、髙瀬良和、岩井謙一、侯德興*：サツマイモ焼酎の冬虫夏草スピリッツの抽出物の機能性解析：①ヒト大腸癌細胞における細胞増殖抑制及びアポトーシス誘導作用. 日本醸造協会誌、110(2):110-116 (2015).
  13. Abe N, Hou DX, Munemasa S, Murata Y, Nakamura Y. Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells. Cell Death Dis. 5:e1534(2014).
  14. Zar PPK, Satoshi Y, Sakao K, Hashimoto F, Nakano T, Fujii M and Hou DX*. In vitro anticancer activity of loquat tea by inducing apoptosis in human leukemia cells. Biosci Biotechnol Biochem, 78(10):1731-1737 (2014).
  15. Hisanaga A, Ishida H, Sakao K, Sogo T, Kumamoto T, Hashimoto F and Hou DX*. Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin. Food Funct. 5(8): 1891-1897(2014).
  16. Qin S, Deng F, Wu W, Jiang L, Yamashiro T, Yano S and Hou DX*: Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms. Arch Biochem Biophys. 559: 53-61(2014).
  17. Trio PZ, You SX, He X, He JH, Sakao K and Hou DX*: Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food & Function, 5(5): 833-844(2014).
  18. Zar PPK, Moroshita A, Hashimoto F, Sakao K, Fujii M, Wada K and Hou DX*. Anti-inflammatory effects and molecular mechanisms of loquat (Eriobotrya japonica) tea. J Functional Foods. 6:523-533(2014).
  19. Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Steve Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX*, Yokoyama KK. Jun dimerization protein 2 is a critical component ofthe Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death Dis. 4:e921(2013)
  20. Qin S, Chen J, Tanigawa S and Hou DX*:　Microarray and pathway analysis highlight Nrf2/ARE-mediated expression profiling by polyphenolic myricetin. Mol Nutr Food Res, 57(3): 435-446(2013).
  21. Korenori Y, Tanigawa S, Kumamoto T, Qin S, Miyamori K, Nagai M and Hou DX*:　Modulation of Nrf2/Keap1 System by Wasabi 6-Methylthiohexyl Isothiocyanate in ARE-mediated NQO1 Expression. Mol Nutr Food Res, 57(5): 854-864 (2013).
  22. You S, Nakanishi E, Kuwata H, Chen J, Nakasone Y, He X, He J, Liu X, Zhang S, Zhang B and Hou DX*. Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators. Mol Nutr Food Res, 57(11):2049-2060 (2013).
  23. Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Steve Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX*, Yokoyama KK. Jun dimerization protein 2 is a critical component ofthe Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death Dis. 4:e921(2013).